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Epstein-Barr Virus (EBV) Vaccine Clinical Trial

A Clinical Trial of an Investigational mRNA Vaccine for Epstein-Barr Virus (EBV)

Epstein-Barr Virus (EBV) Vaccine Clinical Trial

A Clinical Trial of an Investigational mRNA Vaccine for Epstein-Barr Virus (EBV)

A group of friends sit at a table laughing, having conversation and eating food. The message "Some things aren't meant to be shared" appears in the bottom left corner of the image, referring to Epstein-Barr Virus for which their is a clinical trial study of a EBV vaccine.

Trial Details

The Equinox Trial is evaluating the safety and immune response of an investigational vaccine in protecting against EBV and mono.

Research is underway on an investigational vaccine to see if it can protect against EBV and EBV-associated diseases like mono or more serious conditions like post-transplant lymphoproliferative disorders (PTLDs). PTLDs are a group of diseases that resemble cancer and can occur following an organ or stem cell transplant. EBV may result in lifelong infection and the possibility of developing other diseases. Currently, there is no approved vaccine for EBV.

Eligibility Criteria

Participants must be:

   ✅ 18 to 30 years of age

   ✅ In generally good health

   ✅ Willing and able to comply with trial requirements

Participants must NOT be:

🚫 Pregnant or breastfeeding

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WHAT TO EXPECT

Participation in the Equinox Trial will last approximately 12 months and includes about 10 visits to a trial site and 6 safety phone calls.

Participants will be assigned at random to receive 1 of 3 variations of the investigational vaccine or a placebo, and they will receive 3 injections of their assigned treatment.

In order to understand if the investigational vaccine works, medical researchers are comparing the mRNA-1195 investigational vaccine to a saltwater placebo (a solution that looks just like the investigational vaccine but contains no active vaccine).

All trial participants will receive the same level of quality care regardless of which investigational vaccine they receive.

Participants will be asked to use an electronic diary (eDiary) smartphone app to report any side effects on the day of each injection and for at least 6 days after.

Insurance is not needed to participate, and qualified participants will receive payment for their trial-related time and travel.

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A clinical trial is a carefully designed research study involving human volunteers to investigate the safety and effectiveness of a new drug or treatment. Clinical trials are essential for evaluating the benefits and risks of medical interventions, ultimately informing healthcare decisions and regulatory approvals.

As a clinical trial or observational study participant, your responsibilities and what you will be required to do can vary depending on the study, its objectives, and the phase of the trial.

Some common activities and responsibilities you may encounter as a participant include: diagnostic tests, treatments, procedures, doctor visits, dietary changes, exercise and/or other lifestyle changes. Observational studies often involve minimal effort, such as completing questionnaires, sharing test results, maintaining a diet or exercise log.

Joining a clinical trial can provide access to cutting-edge treatments, close medical monitoring, and an opportunity to contribute to medical knowledge. Participants may experience improved health outcomes and specialized care while potentially receiving compensation for volunteering.

Clinical trials are designed with a strong emphasis on the safety of participants, and multiple safeguards are in place to minimize risks, including careful study design, oversight by institutional review boards and routine monitoring of study data by independent experts. Researchers must inform participants of the risks, benefits and/or side effects they discover.

Yes, you can drop out of a clinical trial study at any time, and you have the right to do so without facing any penalties or consequences. This is often referred to as "withdrawal of consent."

Voluntary participation is a fundamental principle of clinical research. You are not obligated to continue in a trial if you no longer wish to do so.

Determining your eligibility to participate in a clinical trial involves a thorough evaluation of specific eligibility criteria set forth by the study's researchers and sponsors. The criteria help define the patient population being studied and are designed to protect the safety of participants in the trial.

Providing accurate information about your medical history and health status is crucial for your safety and the integrity of the research. If you are not eligible for one trial, you may still be eligible for other trials in the future, so it's worth exploring your options if you are interested in participating in clinical research.

Yes, we do! Have a friend or family member who may also want to participate in one of our studies?

For qualifying studies, we offer a $25 gift card for each friend or family member that you refer.  Restrictions apply. Please ask about our referral program  during your screening visit. 

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