ADHD Research Study

A clinical research study evaluating an investigational drug for adults with ADHD.
Benefits of Joining a Clinical Trial
  • Your participation may help researchers learn more about adult ADHD and how different treatments affect the body.
  • Receive study-related care and assessments throughout your participation at no cost.
  • Be closely monitored by the study team throughout the study.
See If You Qualify
Learn more about an ADHD research study
Gender
Male and Female
Ages
18-55
Status
Enrolling

Overview

Find Your Focus. Join an ADHD Research Study.

Researchers are conducting a clinical research study to evaluate an investigational study drug for adults with ADHD. The purpose of this study is to evaluate the drug’s safety, how well it is tolerated, how the body processes it, and its potential effects on attention. 

See If You Qualify

About the Study

The goal of this research study is to gather scientific information. You may or may not benefit from participating in this study. Individual results cannot be guaranteed.

Participants in this study will be randomly assigned to receive one of three dose levels of the investigational study drug or a placebo (a pill that looks the same as the investigational drug but has no active ingredients).

This is a blinded study which means that neither participants nor the study team will know which study treatment has been assigned during the study.

Although this drug has been studied previously in healthy volunteers, researchers are still learning about its safety and whether it may benefit adults living with ADHD.

About the Study Drug

The investigational drug being evaluated in this study is called ORX142. It is being evaluated for adults living with ADHD.

ORX142 is designed to activate the orexin-2 receptor, which plays an important role in regulating wakefulness, attention, and cognitive engagement. Researchers hope to learn whether this investigational drug may influence attention while continuing to evaluate its safety and tolerability. Because this is a research study, it is not known whether the investigational study drug is effective in treating ADHD.

Participants will be randomly assigned to receive one of three dose levels of the investigational drug or a placebo. A placebo looks like the study drug but contains no active ingredients. Random assignment helps researchers compare study results fairly. Neither you nor the study team will know which study treatment you receive during the study.

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Who May Qualify?

You may be eligible to participate if you:
  • Are 18 to 55 years of age
  • Have been diagnosed with ADHD (combined presentation or predominantly inattentive presentation)
  • Have not been diagnosed with any other serious psychiatric conditions (such as bipolar or schizophrenia)
  • Meet additional study requirements determined by the study team
You may not qualify if you:
  • Have certain medical or psychiatric conditions
  • Have previously received an orexin receptor agonist
  • Are pregnant or breastfeeding
  • Do not meet the study’s health and safety requirements
The study doctor will review all eligibility criteria with you to
determine whether this study may be appropriate for you.
Your participation is voluntary. Deciding not to participate in this study will not affect your medical care in any way.
See If You Qualify

What Does Participation Involve?

If you decide to participate, your study journey may include:

SCREENING

  • Review and sign an informed consent form
  • Medical history and physical examination
  • Laboratory testing and ECG ADHD assessments
  • Review of current medications
  • Determine whether you qualify for the study

TREATMENT PERIOD
Participants who qualify will:

  • Take the study drug or placebo once each morning
  • Attend 4 clinic visits (Day 1, Day 7, Day 14, and Day 28)
  • Complete study questionnaires and attention assessments
  • Have blood samples, vital signs, and other safety evaluations performed
  • Complete brief study diaries at home as instructed

FOLLOW-UP
Approximately 14 days after your last study dose, you will
return for a final study visit to complete safety assessments.

COMPENSATION

You may be eligible to receive compensation and reimbursement of reasonable travel expenses.

See If You Qualify

See if You Qualify.

To see if you qualify or to learn more, please complete the form

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Frequently Asked Questions.

What is a Clinical Trial?

A clinical trial is a research study that evaluates new medications, devices, or treatment approaches to determine if they are safe and effective. Clinical trials help doctors and researchers develop better treatments for current and future patients. All studies follow strict safety guidelines and are carefully monitored.
Each clinical study has specific requirements for participants based on factors such as age, medical history, and current health status. The eligibility criteria in each study protocol are used to identify the volunteers best qualified to participate.
No. Study-related medications, lab tests, and medical visits are provided at no cost to you. Participating in a clinical trial should never require you to pay for study-related care.
Many studies provide compensation for your time and travel. Compensation amounts vary by study and will be fully explained before you decide to enroll.
Health insurance is not required for most clinical trials. All study-related care, procedures, and doctor visits are typically provided at no cost to you.
Participation is completely voluntary. You may choose to leave a clinical trial at any time, for any reason. Your decision will not affect your regular medical care or relationship with your doctor.
Each study has specific eligibility criteria. The best way to find out if you qualify is to complete our online eligibility form or speak directly with a member of our research team.
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