Overview
Now Enrolling: Depression Clinical Trial
Investigational oral add-on medication for adults experiencing inadequate relief from daily antidepressant therapy
Living with depression can feel like an uphill battle, especially when your current antidepressant medication isn't giving you the full relief you need. If you are taking a daily antidepressant but still experiencing persistent symptoms, you are not alone. Local medical experts are currently conducting a depression clinical trial to evaluate an investigational oral pill. This study is looking at whether adding this twice-weekly experimental treatment to your current daily antidepressant can safely and quickly help reduce depression symptoms.
About the Study
The main goal of this depression clinical trial is to test the safety and effectiveness of an experimental study medication when it is used alongside your current antidepressant.
To make sure the results are completely fair, this is a double-blind, placebo-controlled study. This means:
- Participants will be randomly assigned to receive either the active investigational pill or a matching “placebo” pill (a dummy pill with no active medicine).
- You will take 3 tablets, twice a week, for 4 weeks.
- Neither you nor the study doctors will know which pill you are taking during the study, but your health will be closely monitored the entire time.
Who Can Join
You may qualify for the depression clinical trial if you:
- Are 18 to 70 years of age.
- Have a diagnosis of Major Depressive Disorder (depression) and are not experiencing symptoms of psychosis.
- Have been experiencing your current episode of depression for at least 8 weeks.
- Have been taking one approved antidepressant medication at a stable dose for at least 8 weeks, but it is not providing enough symptom relief.
- Have a Body Mass Index (BMI) between 19.0 and 40.0.
- Do not have a history of certain psychiatric conditions, including bipolar disorder, schizophrenia, PTSD, autism spectrum disorder, a personality disorder, or severe intellectual disability, and have not been diagnosed within the past year with severe OCD, an eating disorder, panic disorder, or acute stress disorder.
*Additional requirements may apply.
Not sure if you qualify? That’s okay.
A member of our recruitment team will review your medical history and medications with you to see if the depression clinical trial may be right for you.
You may also qualify for other studies.
What to Expect
Here’s what to expect when you participate in our depression clinical trial:
Study Duration
The total time you will spend in the study is up to 7 weeks.
Study Visits
You will participate in a total of 8 scheduled check-ins over the 7-week period.
Study Treatment
- Each dose consists of 3 tablets taken by mouth.
- You will take your dose twice a week (specifically on Days 1, 5, 8, 12, 15, 19, 22, and 26).
- On the days you have a clinic visit (Days 1, 8, and 22), you will take your pills right at the clinic under medical supervision. On the other days, you will take them at home.
Important Note: You must continue taking your current daily antidepressant exactly as prescribed throughout the entire duration of the depression clinical trial without changing the dose.
Compensation
Financial compensation or reimbursement to help cover your time, effort, and travel expenses for completing your study appointments.
Health Assessments & Monitoring
Your safety is the highest priority. At your visits, study doctors will conduct standard medical checks, which include:
- Simple, talk-based questionnaires about your mood and how you are feeling.
- Routine physical exams and vital sign checks (like blood pressure, pulse, and temperature).
- Standard laboratory checks, including routine blood draws and urine tests.
- Quick, completely painless heart traces (called an ECG) to track your heart health.
- A simple smartphone tracking app (provided by the clinic if you need a backup device) to easily log your daily antidepressant and study doses.
