Migraine Clinical Research Study

Check Your Eligibility for a No-Cost Migraine Acute Treatment Study.
Benefits of Joining a Clinical Trial
  • Receive study-related tests, investigational medication, and care at no cost
  • All studies are administered by Board-Certified medical doctors.
  • No health insurance or referrals are required to participate.
  • Compensation of up to $455 may be available for study-related time and travel
See If You Qualify
woman with symptoms who may qualify for a migraine clinical research study
Gender
Male and Female
Ages
18-75
Compensation
$455.00
Status
Enrolling

Overview

Join a Migraine Clinical Research Study

Addressing Migraine can be challenging when standard routines aren’t yielding the results you hope for, but you don’t have to navigate it alone. If you feel stuck, new research study options for the acute treatment of migraine may be available to support your health journey and provide access to potential new treatments.

By joining our migraine clinical research study, you become a vital partner in medical progress. You’ll gain access to study-related investigational medical care and help shape the future of acute migraine treatments for generations to come.

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About the Study

The investigational medication is a novel oral, potent, and highly selective blocker of transient receptor potential melastatin 8 (TRPM8) being developed for the acute treatment of migraine with or without aura in adults.

The migraine clinical research study is designed to evaluate the efficacy of the medication compared with placebo as measured by pain freedom at 2 hours post dose and as measured by freedom from the most bothersome migraine-associated symptom (MBS) at 2 hours post dose.

Specific objective of this migraine clinical research study: 

To evaluate the efficacy of the investigational medication compared to placebo:

  • on pain relief at 60 minutes post dose and 2 hours post-dose

  • on sustained pain freedom from 2 to 48 hours post-dose

  • on freedom from functional disability at 2 hours post dose

  • on freedom from photophobia at 2 hours post dose

  • on freedom from phonophobia at 2 hours post dose

  • on freedom from nausea at 2 hours post dose

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Who Can Join

Inclusion Criteria of this Migraine Clinical Research Study:

  • Be a male or female, age 18 to 75 years

  • Has greater than a one-year history of migraine with or without aura

“With aura” = you get a weird sensory warning before the migraine hits.

“Without aura” = the migraine comes on without those noticeable warning signals.

  • Migraines typically last between 4 to 72 hours, if untreated.

  • Has had >2 and ≤10 moderate or severe migraine attacks per month in each of the two months prior to screening.

  • Females of reproductive potential must agree to remain abstinent or use an acceptable birth control method.

Exclusion Criteria:

  • Has difficulty distinguishing his/her migraine attacks from tension-type headaches.

  • Has a history of predominantly mild migraine attacks or migraines that usually resolve spontaneously in less than two hours.

  • Has more than 15 headache-days per month.

  • Is a female who is pregnant, breast-feeding or intends to become pregnant during the course of the study.

*Other conditions may apply

Not sure if you qualify?

A member of our study team will review your medical history and medications with you to determine if this migraine clinical research study may be a good fit.

You may also qualify for other studies.

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What to Expect

Here’s what to expect when you participate in this migraine clinical research study:

Study Duration

The studied period for each participant is a single dose, with participation lasting up to 45 days. Patients will return to the study site within 5 to 8 days after treatment to allow review of the eDiary, assessment of medication compliance, and safety monitoring.

Number of Visits

Study Visit Schedule:

  • Visit 1 (Screening): Conducted within -28 days to Visit 2 to determine eligibility.

  • Visit 2 (Randomization): Occurs on Day 0 where patients are provided with study medication to be taken on an outpatient basis.

  • Visit 3 (End of Study): Conducted 5 to 8 days after treating a qualifying migraine attack.

Procedures

Patients will use an electronic diary (eDiary) to record migraine-related information. Upon experiencing a potentially qualifying headache, subjects will log in and answer questions to ascertain whether the migraine headache is qualifying for treatment. During the 48 hours following the dose of study medication, patients will record various measures in the eDiary at specified time intervals, including pain severity and presence of migraine-associated symptoms.

If a patient has not experienced a qualifying migraine headache within 45 days after randomization, he or she will be withdrawn from the trial and instructed to return the unused study medication to the study center.

Compensation

Details regarding reimbursement for study-related expenses will be discussed with the clinical site staff during the screening process.

Need More Details? 

The study team will explain all procedures, site visits, and other requirements in detail before you decide to participate in this migraine clinical research study.

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See if You Qualify.

To see if you qualify or to learn more, please complete the form

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Frequently Asked Questions.

What is a Clinical Trial?

A clinical trial is a research study that evaluates new medications, devices, or treatment approaches to determine if they are safe and effective. Clinical trials help doctors and researchers develop better treatments for current and future patients. All studies follow strict safety guidelines and are carefully monitored.
Each clinical study has specific requirements for participants based on factors such as age, medical history, and current health status. The eligibility criteria in each study protocol are used to identify the volunteers best qualified to participate.
No. Study-related medications, lab tests, and medical visits are provided at no cost to you. Participating in a clinical trial should never require you to pay for study-related care.
Many studies provide compensation for your time and travel. Compensation amounts vary by study and will be fully explained before you decide to enroll.
Health insurance is not required for most clinical trials. All study-related care, procedures, and doctor visits are typically provided at no cost to you.
Participation is completely voluntary. You may choose to leave a clinical trial at any time, for any reason. Your decision will not affect your regular medical care or relationship with your doctor.
Each study has specific eligibility criteria. The best way to find out if you qualify is to complete our online eligibility form or speak directly with a member of our research team.
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